November 8, 2016
Media contact: Leigh DeLozier, (404) 778-3711
The acute outbreak of Ebola virus disease (EVD) has subsided in West Africa, but the medical community continues to learn about long-term complications for survivors – including the potential for blinding eye disease. One particular condition of concern is uveitis, according to research published in the December 2016 issue of Ophthalmology by physicians from the Emory Eye Center and ELWA Hospital in Monrovia, Liberia.
“Uveitis” refers to inflammation of the eye, which can lead to problems ranging from mildly reduced vision to severe vision loss and blindness. Patients with uveitis can experience eye redness, blurred vision, eye pain, headache and/or sensitivity to light.
The Ophthalmology study reports on nearly 100 EVD survivors in Monrovia, Liberia (the countries most affected by the EVD outbreak were Liberia, Sierra Leone and Guinea). More than 10,000 cases of EVD were reported in Liberia alone during the recent outbreak; over 28,000 cases were reported during the West African EVD Outbreak between 2013 and 2016.
“Previous outbreaks have provided limited information on the long-term sequelae after EVD,” says Dr. Steven Yeh, associate professor of Ophthalmology in the Emory University School of Medicine. “Being able to work with survivors now gives us many opportunities to understand the ophthalmic and systemic sequelae that affects survivors after recovery from their acute illness.”
The Liberian survivors were examined by Dr. Yeh, Dr. Jessica Shantha, Dr. Brent Hayek, and Dr. Ian Crozier in partnership with ELWA Lead Clinician Dr. John Fankhauser. They worked with survivors to learn about the frequency of uveitis and other ocular conditions including optic nerve damage, the level of visual impairment in survivors with eye disease, and any structural complications including cataract. Joint pains, hearing loss and hair loss were also observed frequently in EVD survivors.
“This has been a great opportunity to help survivors with EVD uveitis and also help them better understand the vision issues that come as a result,” Hayek says. “We’ve also been able to teach and train local providers in Liberia how to best screen and examine survivors with ocular issues and use a mobile clinic design to do it most efficiently.”
Of the 96 patients examined, 21 had developed an EVD-associated uveitis and three developed an EVD-associated optic neuropathy. In addition, nearly 40% of the eyes with uveitis were legally blind, based on the World Health Organization (WHO) classification. Other findings include cataract and vitreous opacity, which can both be complications of untreated uveitis.
“Cataract and vitreous opacities were identifiable causes of vision loss in our patient cohort,” Yeh says. “These findings have implications from medical and surgical perspectives, particularly given our prior finding of live Ebola virus in the ocular fluid of a recovered Ebola survivor.”
The public health risk in these cases lies in knowing what kinds of precautions health care workers should take when treating Ebola survivors who develop cataracts. WHO officials have established interim guidelines for caring for EVD survivors in West Africa. Guidelines related to invasive ophthalmic procedures – such as cataract surgery – are still being developed by the WHO, Emory Eye Center and collaborators in West Africa.
The findings from the study published in Ophthalmology emphasize the tremendous need for mobilization of resources and funding for EVD survivors throughout West Africa, who are at ongoing risk of uveitis and severe vision loss although the acute EVD outbreak has concluded.
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